The combination of Sintilimab with pemetrexed/platinum has become the first-line treatment for non-squamous non-small-cell lung carcinoma (NSCLC).Here, we report a patient with metastatic large cell neuroendocrine carcinoma (LCNEC) treated with Sintilimab for five cycles who developed shortness of breath after activity.The level of creatine kinase
Biodiesel, a renewable and biodegradable energy source, presents a sustainable alternative to conventional fossil fuels, facilitating the transition towards sustainable energy frameworks.The synthesis of Lower Spray Arm biodiesel is predicated on transesterification, a chemical process that transforms triglycerides into fatty acid methyl esters (FA
The Orf virus (ORFV; Parapoxvirus) strain D1701 with an attenuated phenotype and excellent immunogenic capacity is successfully used for the generation of recombinant vaccines against different viral infections.Adaption for growth in Vero cells was accompanied by additional major genomic changes resulting in Sports Bra ORFV strain variant D1701-V.I
There is growing concern that poor experimental design and lack of transparent reporting contribute to the frequent failure of pre-clinical animal studies to translate FME Plug to SMA into treatments for human disease.In 2010, the Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines were introduced to help improve reporting standar
In a globalized world, the threat of emerging pathogens plays an increasing role, especially if their zoonotic potential is unknown.In this study, a novel respirovirus, family Paramyxoviridae, was isolated from a Sri Lankan Giant squirrel (Ratufa macroura), which originated in Sri Lanka and deceased with severe pneumonia in a German zoo.The full-ge